A small tool to view real-world ActivityPub objects as JSON! Enter a URL
or username from Mastodon or a similar service below, and we'll send a
request with
the right
Accept
header
to the server to view the underlying object.
{
"@context": [
"https://www.w3.org/ns/activitystreams",
{
"ostatus": "http://ostatus.org#",
"atomUri": "ostatus:atomUri",
"inReplyToAtomUri": "ostatus:inReplyToAtomUri",
"conversation": "ostatus:conversation",
"sensitive": "as:sensitive",
"toot": "http://joinmastodon.org/ns#",
"votersCount": "toot:votersCount"
}
],
"id": "https://rukii.net/users/tero/statuses/113367867163197473/activity",
"type": "Create",
"actor": "https://rukii.net/users/tero",
"published": "2024-10-25T11:39:31Z",
"to": [
"https://www.w3.org/ns/activitystreams#Public"
],
"cc": [
"https://rukii.net/users/tero/followers"
],
"object": {
"id": "https://rukii.net/users/tero/statuses/113367867163197473",
"type": "Note",
"summary": null,
"inReplyTo": null,
"published": "2024-10-25T11:39:31Z",
"url": "https://rukii.net/@tero/113367867163197473",
"attributedTo": "https://rukii.net/users/tero",
"to": [
"https://www.w3.org/ns/activitystreams#Public"
],
"cc": [
"https://rukii.net/users/tero/followers"
],
"sensitive": false,
"atomUri": "https://rukii.net/users/tero/statuses/113367867163197473",
"inReplyToAtomUri": null,
"conversation": "tag:rukii.net,2024-10-25:objectId=318818611:objectType=Conversation",
"content": "<p>Objectives such as curing all cancers seem distant because we have habitually become to think about them as distant. But if you consider technologies we have, you will see that the path between here and there is just a lot of work, no magic.</p><p>For example, we already have generalist mRNA vaccines, thanks to the pandemic the research was completed very fast, and these give us a capability to encode any arbitrary protein to cells.</p><p>Proteins sound like something boring, stuff you get if you eat meat. It's not though. Proteins are pretty much nanotech.</p><p>Already mRNA vaccines have been used to encode strategic, but alone non-functional parts of viruses, to make the immune defence attack these parts. In cancer care they have been used to encode antigens which similarly promote an immune response against transformed (cancer) cells, but there have been a host of other approaches as well.</p><p>This is really just scratching the surface. It is in principle possible to engineer a protein which only activates inside transformed cells or tumor microenvironments. Once activated, the protein can be engineered to do whatever. Induce apoptosis, or use e.g. CRISPR-CAS to destroy the DNA of the transformed cell. It's useful to note that many cancer cells have disabled their own DNA repair machinery, so it makes DNA an inherently vulnerable target for them.</p><p>Just simply by engineering mRNA in a tailored, intelligent fashion, we could in principle cure pretty much all cancers.</p><p>How do we get there? Engineering non-trivial proteins is beyond human capability, and simulating their effects as well. But it isn't beyond AI capability. We can leverage AlphaFold-like architectures to make an AI able to engineer mRNA sequences, and clinical oncological AIs to understand best targets for each case, in concert in effect designing most effective interventions for each specific case.</p><p>This isn't a pipe dream. It is just work. Maybe quite a lot of work, but we must do it.</p>",
"contentMap": {
"en": "<p>Objectives such as curing all cancers seem distant because we have habitually become to think about them as distant. But if you consider technologies we have, you will see that the path between here and there is just a lot of work, no magic.</p><p>For example, we already have generalist mRNA vaccines, thanks to the pandemic the research was completed very fast, and these give us a capability to encode any arbitrary protein to cells.</p><p>Proteins sound like something boring, stuff you get if you eat meat. It's not though. Proteins are pretty much nanotech.</p><p>Already mRNA vaccines have been used to encode strategic, but alone non-functional parts of viruses, to make the immune defence attack these parts. In cancer care they have been used to encode antigens which similarly promote an immune response against transformed (cancer) cells, but there have been a host of other approaches as well.</p><p>This is really just scratching the surface. It is in principle possible to engineer a protein which only activates inside transformed cells or tumor microenvironments. Once activated, the protein can be engineered to do whatever. Induce apoptosis, or use e.g. CRISPR-CAS to destroy the DNA of the transformed cell. It's useful to note that many cancer cells have disabled their own DNA repair machinery, so it makes DNA an inherently vulnerable target for them.</p><p>Just simply by engineering mRNA in a tailored, intelligent fashion, we could in principle cure pretty much all cancers.</p><p>How do we get there? Engineering non-trivial proteins is beyond human capability, and simulating their effects as well. But it isn't beyond AI capability. We can leverage AlphaFold-like architectures to make an AI able to engineer mRNA sequences, and clinical oncological AIs to understand best targets for each case, in concert in effect designing most effective interventions for each specific case.</p><p>This isn't a pipe dream. It is just work. Maybe quite a lot of work, but we must do it.</p>"
},
"attachment": [],
"tag": [],
"replies": {
"id": "https://rukii.net/users/tero/statuses/113367867163197473/replies",
"type": "Collection",
"first": {
"type": "CollectionPage",
"next": "https://rukii.net/users/tero/statuses/113367867163197473/replies?only_other_accounts=true&page=true",
"partOf": "https://rukii.net/users/tero/statuses/113367867163197473/replies",
"items": []
}
}
}
}