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"content": "<p>Resilience to autosomal dominant Alzheimer’s disease in a Reelin-COLBOS heterozygous man</p><p>The male remained cognitively intact until 67 years of age despite carrying a PSEN1-E280A mutation. He had extremely elevated amyloid plaque burden and limited entorhinal Tau tangle burden.<br />He was heterozygous for a rare variant in RELN showing stronger ability to reduce human Tau phosphorylation in a knockin mouse.</p><p><a href=\"https://red.niboe.info/tags/Biomedicine\" class=\"mention hashtag\" rel=\"tag\">#<span>Biomedicine</span></a> <a href=\"https://red.niboe.info/tags/Neuroscience\" class=\"mention hashtag\" rel=\"tag\">#<span>Neuroscience</span></a> <a href=\"https://red.niboe.info/tags/Brain\" class=\"mention hashtag\" rel=\"tag\">#<span>Brain</span></a> <a href=\"https://red.niboe.info/tags/Neurology\" class=\"mention hashtag\" rel=\"tag\">#<span>Neurology</span></a> <a href=\"https://red.niboe.info/tags/NeurologicalDiseases\" class=\"mention hashtag\" rel=\"tag\">#<span>NeurologicalDiseases</span></a> <a href=\"https://red.niboe.info/tags/NeurodegenerativeDiseases\" class=\"mention hashtag\" rel=\"tag\">#<span>NeurodegenerativeDiseases</span></a> <a href=\"https://red.niboe.info/tags/Neurodegeneration\" class=\"mention hashtag\" rel=\"tag\">#<span>Neurodegeneration</span></a> <a href=\"https://red.niboe.info/tags/Alzheimer\" class=\"mention hashtag\" rel=\"tag\">#<span>Alzheimer</span></a> <a href=\"https://red.niboe.info/tags/Tau\" class=\"mention hashtag\" rel=\"tag\">#<span>Tau</span></a> <a href=\"https://red.niboe.info/tags/Reelin\" class=\"mention hashtag\" rel=\"tag\">#<span>Reelin</span></a> <a href=\"https://red.niboe.info/tags/ApoE\" class=\"mention hashtag\" rel=\"tag\">#<span>ApoE</span></a> <a href=\"https://red.niboe.info/tags/Dementia\" class=\"mention hashtag\" rel=\"tag\">#<span>Dementia</span></a> <a href=\"https://red.niboe.info/tags/Neurogenetics\" class=\"mention hashtag\" rel=\"tag\">#<span>Neurogenetics</span></a> </p><p><a href=\"https://www.nature.com/articles/s41591-023-02318-3\" rel=\"nofollow noopener noreferrer\" target=\"_blank\"><span class=\"invisible\">https://www.</span><span class=\"ellipsis\">nature.com/articles/s41591-023</span><span class=\"invisible\">-02318-3</span></a></p>",
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