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"content": "<p>A remarkable finding from Shapson-Coe et al. 2024 paper on human brain <a href=\"https://mathstodon.xyz/tags/connectomics\" class=\"mention hashtag\" rel=\"tag\">#<span>connectomics</span></a>: the presence of canalized connections in the human brain cortex. Canalized in the Kauffman boolean networks sense [1], which here means: among the many synaptic inputs that any one neuron integrates, some are far stronger (by number of synapses) than the rest.</p><p>This is a pattern that we described in the <a href=\"https://mathstodon.xyz/tags/Drosophila\" class=\"mention hashtag\" rel=\"tag\">#<span>Drosophila</span></a> larval nervous system (Ohyama et al. 2015 <a href=\"https://www.nature.com/articles/nature14297\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" translate=\"no\"><span class=\"invisible\">https://www.</span><span class=\"ellipsis\">nature.com/articles/nature1429</span><span class=\"invisible\">7</span></a> ) and that has been reported as well for the mouse hippocampus (Bartol et al. 2015 <a href=\"https://elifesciences.org/articles/10778\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" translate=\"no\"><span class=\"invisible\">https://</span><span class=\"ellipsis\">elifesciences.org/articles/107</span><span class=\"invisible\">78</span></a> ) and cerebellum (Nguyen et al. 2023 <a href=\"https://www.nature.com/articles/s41586-022-05471-w\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" translate=\"no\"><span class=\"invisible\">https://www.</span><span class=\"ellipsis\">nature.com/articles/s41586-022</span><span class=\"invisible\">-05471-w</span></a> ).</p><p>[1] Canalisation as a term was introduced by Waddington in 1942 in the context of genetics to mean "some phenotypic traits are very robust to small perturbations" <a href=\"https://en.wikipedia.org/wiki/Canalisation_(genetics)\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" translate=\"no\"><span class=\"invisible\">https://</span><span class=\"ellipsis\">en.wikipedia.org/wiki/Canalisa</span><span class=\"invisible\">tion_(genetics)</span></a></p><p><a href=\"https://mathstodon.xyz/tags/neuroscience\" class=\"mention hashtag\" rel=\"tag\">#<span>neuroscience</span></a> <a href=\"https://mathstodon.xyz/tags/connectomics\" class=\"mention hashtag\" rel=\"tag\">#<span>connectomics</span></a></p>",
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"en": "<p>A remarkable finding from Shapson-Coe et al. 2024 paper on human brain <a href=\"https://mathstodon.xyz/tags/connectomics\" class=\"mention hashtag\" rel=\"tag\">#<span>connectomics</span></a>: the presence of canalized connections in the human brain cortex. Canalized in the Kauffman boolean networks sense [1], which here means: among the many synaptic inputs that any one neuron integrates, some are far stronger (by number of synapses) than the rest.</p><p>This is a pattern that we described in the <a href=\"https://mathstodon.xyz/tags/Drosophila\" class=\"mention hashtag\" rel=\"tag\">#<span>Drosophila</span></a> larval nervous system (Ohyama et al. 2015 <a href=\"https://www.nature.com/articles/nature14297\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" translate=\"no\"><span class=\"invisible\">https://www.</span><span class=\"ellipsis\">nature.com/articles/nature1429</span><span class=\"invisible\">7</span></a> ) and that has been reported as well for the mouse hippocampus (Bartol et al. 2015 <a href=\"https://elifesciences.org/articles/10778\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" translate=\"no\"><span class=\"invisible\">https://</span><span class=\"ellipsis\">elifesciences.org/articles/107</span><span class=\"invisible\">78</span></a> ) and cerebellum (Nguyen et al. 2023 <a href=\"https://www.nature.com/articles/s41586-022-05471-w\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" translate=\"no\"><span class=\"invisible\">https://www.</span><span class=\"ellipsis\">nature.com/articles/s41586-022</span><span class=\"invisible\">-05471-w</span></a> ).</p><p>[1] Canalisation as a term was introduced by Waddington in 1942 in the context of genetics to mean "some phenotypic traits are very robust to small perturbations" <a href=\"https://en.wikipedia.org/wiki/Canalisation_(genetics)\" target=\"_blank\" rel=\"nofollow noopener noreferrer\" translate=\"no\"><span class=\"invisible\">https://</span><span class=\"ellipsis\">en.wikipedia.org/wiki/Canalisa</span><span class=\"invisible\">tion_(genetics)</span></a></p><p><a href=\"https://mathstodon.xyz/tags/neuroscience\" class=\"mention hashtag\" rel=\"tag\">#<span>neuroscience</span></a> <a href=\"https://mathstodon.xyz/tags/connectomics\" class=\"mention hashtag\" rel=\"tag\">#<span>connectomics</span></a></p>"
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